Ephedrine

Ephedrine 30 mg/1ml
Each ampoule (1 ml ) contains: Ephedrine HCL 30 mg.

Company Name
CID
Therapeutic Group
ALL OTH A-AS & COPD. SYS
Pharmaceutical Form
Ampoule
Package
A carton box containing 100 ampoules each of 1ml.
Indications
- Ephedrine ampoule is used as an emergency method for elevating blood pressure in case reversal of hypotension from spinal or epidural anaesthesia and management of associated bradycardia . - Ephedrine can be used as bronchodilator in case of reversible airways obstruction if clearly needed .
Warning & Precautions
Ephedrine is used with caution in case of hyperthyroidism, diabetes mellitus, ischaemic heart disease, hypertension , Prostatic hypertrophy , hypovolemia, angle closure glaucoma, elderly patients and pregnancy .
Product Type human       Dosage -For reversal of hypotension from spinal or epidural anesthesia : 0.25ml of Ephedrine ampoule (30mg/ml) is given by slow intravenous injection and repeated every 3-4 minutes according to response to maximum 1ml (30mg). -Ephedrine ampoule can also be injected intramuscularly or subcutaneously .       Adverse Reactions - The commonest side effects of Ephedrine are : anxiety , restlessness , insomnia, tremor and tachycardia , Hypertension , seizures , hallucination , palpitation and arrythmias and anginal pain may occur . - Nausea , vomiting , dizziness, anorexia , headache , flushing , urine retention , sweating, hyperglycemia, stinging, contact dermatitis may rearly occur.       Contra Indications Ephedrine is contra-indicated in case of breast feeding and narrow angle glaucoma .       Drug Interactions - Risk of hypertension crisis :when Ephedrine given with MAOIs, meclobemide, doxapram or oxytocin . - Hypertensive effect of sympathomimetics is antagonized by antipsychotics. - Ephedrine antagonizes hypotensive effect of adrenergic neuron blockers and may accelerate the metabolism of dexamethasone . - Possible hypertensive effect with furazolidine . - Inhibition of antihypertensive effect of guanethidine . - Increased serum concentration by antacids . - False increased of urine amino acids and urine 5- HIAA

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