Linopril tablet

Linopril tablet
Each tablet contains :
Lisinopril  10 or 20 mg .

Company Name
CID
Therapeutic Group
ACE INHIBITORS PLAIN
Pharmaceutical Form
Tablets
Package
<div>Carton box&nbsp; containing 10 tablets</div>
Indications
- Essential and reno-vascular hypertension. - Congestive heart failure. - Following acute myocardial infarction in haemodynamically stable patients. - Diabetic nephropathy in normotensive insulin dependent. - Hypertensive non insulin dependent diabetes mellitus.
Warning & Precautions
- Renal function and electrolytes should be checked before use - Concomitant treatment with non steroidal anti-inflammatory drugs  increase the risk of renal damage . - Use in pregnancy  : when  pregnancy is detected , lisinopril should be discontinued as soon as  possible .
Product Type Human       Dosage - Hypertension  : Initial therapy: 10 mg once daily . Usual dosage range : ( 20 – 40 ) mg daily as a single daily dose . - Heart failure : Initial therapy : 5 mg once daily . Usual dosage range   : ( 5 – 20 ) mg daily as a single daily dose . - Acute myocardial infarction : Within 24 hours of the onset of myocardial infarction , the first dose is 5 mg  followed by 5 mg after 24 hours then 10 mg after 48 hours then 10 mg once daily. Dosing should continue for 6 weeks . - Diabetic nephropathy : Initial therapy :  2.5 mg daily . Usual dosage range   : ( 10 – 20 ) mg daily . N.B. : Where this drug is replaced by beta -adrenoreceptor blocking agents , these agents should be withdrawn gradually .  Dose should be reduced in renal impairment .       Adverse Reactions - It may cause angioedema , skin rash , pruritus and urticaria , persistent dry cough, sinusitis , gastro-intestinal disturbances and blood dyscrasia . - Hypotension may occur especially in patients taking high doses of diuretics, on low sodium diet , on dialysis or dehydrated .       Contra Indications - Patients with known or suspected renovascular diseases unless the blood pressure cannot be controlled by other drugs . - Patients hypersensitive to ACE inhibitors ( including angioedema ) .       Drug Interactions - Excessive hypotension may occur when Lisinopril is used concurrently with diuretics, other anti-hypertensives or other agents, including alcohol, that lower blood pressure  . - An additive hyperkalemic effect is possible in patients receiving Lisinopril with potassium – sparing diuretics , potassium  supplements or other drugs that can cause hyperkalaemia ( e.g. ciclosporin or indometacin ) .

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